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Conditions InDepth: Celiac Disease

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Main Page Risk Factors Symptoms Diagnosis Treatment Screening Reducing Your Risk Talking to Your Doctor Living With Celiac Disease Resource Guide

Celiac disease (also called celiac sprue, nontropical sprue, and gluten-sensitive enteropathy) is an autoimmune disease affecting the digestive tract. When people with celiac disease eat food with gluten—a type of protein found in wheat, rye, barley, and oats—it provokes an immune reaction that causes flattening and damage to the small protrusions (villi) in the small intestine that absorb nutrients.

The resulting smooth surface in the lining of the intestine inhibits the ability to digest and absorb nutrients in many, if not all, foods. As a result, people with untreated celiac disease can suffer from malnutrition and a host of symptoms caused by malnutrition. Thus, celiac disease is also classified as a disease of malabsorption.

The Digestive Tract
Diagram of total or simple mastectomy
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It is not known exactly why people with celiac disease react to gluten-containing foods in such a negative manner. If you have celiac disease, chances are that approximately 10% of your immediate family does, too. The disease can occur at any age. In some cases, symptoms of the disease do not emerge until after some form of trigger. Triggers can include an infection, pregnancy, severe stress, surgery, or physical injury. To prevent symptoms, a person with celiac disease must avoid foods containing gluten.

What are the risk factors for celiac disease?What are the symptoms of celiac disease?How is celiac disease diagnosed?What are the treatments for celiac diseaseAre there screening tests for celiac disease?How can I reduce my risk of celiac disease?What questions should I ask my doctor?What is it like to live with celiac disease?Where can I get more information about celiac disease?
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Revision Information

  • Reviewer: Daus Mahnke, MD
  • Review Date: 09/2012 -
  • Update Date: 09/11/2012 -

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Copyright © EBSCO Publishing
All rights reserved.

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  • Celiac Disease
  • Conditions InDepth: Celiac Disease
  • Diagnosis of Celiac Disease
  • Lifestyle Changes to Manage Celiac Disease
  • Medications for Celiac Disease
  • Other Treatments for Celiac Disease
  • Reducing Your Risk of Celiac Disease
  • Resource Guide for Celiac Disease
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References

  • American Academy of Family Physicians website. Available at: http://www.aafp.org/ . Accessed March 9, 2006.

  • Berkow R. The Merck Manual of Medical Information. 17th ed. New York, NY: Simon and Schuster, Inc; 2000.

  • Collin P, Thorell L, Kaukinen K, Maki M. The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease? Aliment Pharmacol Ther. 2004;19:1277.

  • Mayo Foundation for Medical Education and Research website. Available at: http://www.mayo.edu/ . Accessed March 9, 2006.

  • National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: http://www.niddk.nih.gov/ . Accessed March 9, 2006.

  • Rostom, A, Dube, C, Cranney, A, et al. Celiac disease. Summary, evidence report/technology assessment No 104. Rockville, MD: Agency for Healthcare Research and Quality; 2004.

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Brentwood, TN 37027
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